Similac 360 Total Care is the only infant formula brand to have our unique blend of 5 HMOs.
New clinical evidence1,2: The largest and longest US study evaluating infant formula with HMOs.*
* A clinical study through 12 months of age that enrolled 607 infants fed Similac 360 Total Care, formula without HMOs, or breast milk in the US (Reverri et al. 2024, Reverri et al. 2025).
Growth like that of breastfed infants‡:
• Weight
• Length
• Weight-for-Length
• Head Circumference
Infants fed Similac 360 Total Care had clinically shown results in language and social development like breastfed infants at 12 months of age.§
Clinically shown to be well-tolerated.ǁ
Infants fed Similac 360 Total Care had increased growth of beneficial gut bacteria.¶
Similac 360 Total Care with 5 HMOs has been clinically shown to positively impact the developing immune system.#
† In infants fed Similac 360 Total Care at or during the first 6 months of age and cognition at 12 months of age. Brain development refers to clinically shown benefits in language and social development like breastfed babies (Reverri et al. 2024, Reverri et al. 2025).
‡ In a clinical study at 6 months of age, growth among infants fed Similac 360 Total Care, formula without HMOs, or breast milk was not significantly different (Reverri et al. 2024).
§ Measured by parent-reported MacArthur-Bates Communicative Development Inventories (Phrases Understood, Imitation when Starting to Talk) and Bayley Scales of Infant and Toddler Development (Adaptive Behavior, Socialization, Interpersonal Relationships, and Play and Leisure Scores) (Reverri et al. 2025).
|| In a clinical study through 6 months of age comparing infants fed Similac 360 Total Care, formula without HMOs, or breast milk (Reverri et al. 2024).
¶ In a clinical study, growth of a group of 5 species of infant-specific Bifidobacterium was like breastfed infants and greater than infants fed a formula without HMOs at 6 months of age (AN Data on File 2024).
# As compared to formula without HMOs, at 6 months of age comparing infants fed Similac 360 Total Care, formula without HMOs, or breast milk (Reverri et al. 2024, Reverri et al. 2025).
** Measured by parent-reported MacArthur-Bates Communicative Development Inventories (Phrases Understood, Imitation when Starting to Talk) and Bayley Scales of Infant and Toddler Development (Adaptive Behavior, Socialization, Interpersonal Relationships, and Play and Leisure Scores) at 12 months of age; Other cognitive assessment measures were not significantly different among groups; ‘Performance like’ refers to no significant differences in scores; ‘Were developing relationship skills’ is about responding and relating to others (AN Data on File 2024).
References: 1. Reverri EJ, et al. JPGN Reports. 2024;5(S2):S468. 2. Reverri EJ, et al. Cognitive outcomes after 12 months of feeding an infant formula with 5 specific human milk oligosaccharides: a large, randomized, controlled trial. Abstract accepted at: 57th Annual Meeting of the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition; May 15, 2025; Helsinki, Finland.
†† Enfamil was not used in the previously mentioned clinical study.
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