Similac offers the FIRST nonacidified human milk fortifier that has extensively hydrolyzed protein.
Similac Human Milk Fortifier Hydrolyzed Protein Concentrated Liquid (HMF HP CL) infants gained 0.5 lb more weight at study day 29, and both groups increased in weight and length over time
Similac HMF HP CL delivers 4.3g† of protein (g/kg/day)
Evaluable patients (n = 75).‡
Hash marks indicate standard error.
Extensively hydrolyzed protein source to help promote easy digestion
Has OptiGRO® for brain and eye development
Low iron level provides flexibility to add iron as needed
Well tolerated
Only 1 in 66 (1.5%) NICU patients in the Similac HMF HP CL group discontinued due to feeding intolerance
No incidence of metabolic acidosis with infants fed Similac HMF HP CL or control
Improved protein status
Recent studies have identified blood urea nitrogen (BUN) levels of >9 mg/dL as an indicator of protein sufficiency in preterm infants2-4
BUN levels remained above 9 mg/dL in preterm infant receiving Similac HMF HP CL
In vitro study of human milk acidified with citric acid to a pH of 4.55
Similac HMF retains the pH of human milk to near neutral range, which should preserve the unique benefits of human milk.
† Composition of human milk-based feedings at 120 kcal/kg and 24 Cal/fl oz.
* Weight, g. Repeated Measures Analysis main effect, P = 0.036; post hoc per timepoint analysis: SDAY 29, P = 0.024. Length, cm. Repeated Measures Analysis main effect, P = 0.029; post hoc per timepoint analysis: SDAY 22, P = 0.006; SDAY 29, P = 0.037.
‡ These infants strictly adhered to study protocol and received ≥95% of their total intake from human milk with their assigned study fortifier.
References: 1. Kim JH, et al. J Pediatr Gastroenterol Nutr. 2015;61(6):605-671. 2. Arslanoglu S, et al. J Perinatol. 2006;26:614-621. 3. Alan S, et al. Early Hum Dev. 2013;89:1017-1023. 4. Ergenekon E, et al. Turk J Pediatr. 2013;55:365-370. 5. Erickson T, et al. J Perinatol. 2013;33:371-373.
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